Table 2 Clinical variables and metabolites in association with the time to HCC occurrence.

From: Plasma phenylalanine and glutamine concentrations correlate with subsequent hepatocellular carcinoma occurrence in liver cirrhosis patients: an exploratory study

Variables

Univariate analysis

Multivariate analysis (7 variables)

Multivariate analysis (4 variables)

HR

95% CI

P

HR

95% CI

P

HR

95% CI

P

Age (years)

1.072

1.040

1.106

 < 0.001

1.065

1.031

1.101

 < 0.001

1.064

1.030

1.098

 < 0.001

Gender—male

0.677

0.361

1.271

0.225

        

HBV

0.698

0.372

1.308

0.261

        

HCV

3.277

1.731

6.204

 < 0.001

2.685

1.406

5.129

0.030

2.619

1.377

4.979

0.030

AST

1.004

1.001

1.008

0.022

1.002

0.997

1.008

0.366

    

ALT

1.003

1.000

1.007

0.091

        

AST/ALT

1.073

0.579

1.988

0.823

        

Platelet

0.998

0.992

1.003

0.443

        

FIB-4 index

1.039

0.996

1.085

0.079

        

Metabolites assessed by NMR

Phe

1.056

1.015

1.098

0.006

1.060

1.004

1.120

0.037

1.061

1.003

1.122

0.037

HDL-CH3

0.998

0.996

0.999

0.005

0.998

0.996

1.001

0.181

    

Gln

0.984

0.973

0.995

0.005

0.986

0.972

1.000

0.046

0.986

0.975

0.997

0.011

Ketoglutarate

0.990

0.982

0.999

0.022

1.009

0.996

1.022

0.180

    
  1. P values less than 0.05 are indicated in bold.
  2. HBV, hepatitis B virus; HCV, hepatitis C virus; AST, aspartate transaminase; ALT, alanine transaminase; FIB-4, fibrosis-4; Phe, phenylalanine; HDL, high-density lipoprotein; Gln, glutamine.
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