Table 3 The correlation between bilirubin values obtained from AJO-Neo and TSB along with predictive indices of AJO-Neo in neonates with AAP designated risk factors of hyperbilirubinemia.

From: Large scale validation of a new non-invasive and non-contact bilirubinometer in neonates with risk factors

Risk factors	Statistical test	Parameters		Right thumb nail plate	Left thumb nail plate
ABO incompatibility	Linear regression analysis	Regression coefficient (r)		0.78	0.75
		P value		< 0.0001	< 0.0001
		Slope		0.98	0.98
		Intercept		0.84	0.85
	Bland altman analysis	Bias (95% CI)		0.71 (0.47 to 0.96)	0.66 (0.39 to 0.91)
		Standard deviation		1.92	1.98
		Limits of agreement		− 3.04 to 4.48	− 3.31 to 4.63
	Accuracy	Above 95th percentile	Sensitivity	0.85	0.88
			Specificity	0.98	0.98
			PPV	0.85	0.88
			NPV	0.91	0.98
		Above 75th percentile	Sensitivity	0.70	0.85
			Specificity	0.94	0.94
			PPV	0.85	0.85
			NPV	0.87	0.87
		Above 40th percentile	Sensitivity	0.80	0.80
			Specificity	0.91	0.88
			PPV	0.90	0.87
			NPV	0.82	0.81
Rh incompatibility	Linear regression analysis	Regression Coefficient (r)		0.73	0.71
		P value		0.55	0.08
		Slope		0.59	0.55
		Intercept		3.80	4.38
	Bland altman analysis	Bias (95% CI)		0.54 (− 0.10 to 1.18)	0.411 (− 0.25 to 1.07)
		Standard deviation		2.29	2.37
		Limits of agreement		− 3.96 to 2.84	− 3.24 to 2.06
	Accuracy	Above 95th percentile	Sensitivity	0.00	0.16
			Specificity	1.00	1.00
			PPV	0.00	1.00
			NPV	0.88	0.90
		Above 75th percentile	Sensitivity	0.60	0.60
			Specificity	0.92	0.95
			PPV	0.66	0.75
			NPV	0.90	0.90
		Above 40th percentile	Sensitivity	0.80	0.65
			Specificity	0.93	0.87
			PPV	0.88	0.76
			NPV	0.87	0.79
G6PD deficiency	Linear regression analysis	Regression Coefficient (r)		0.84	0.70
		P value		0.55	0.08
		Slope		0.47	0.50
		Intercept		5.48	5.15
	Bland altman analysis	Bias (95% CI)		0.03 (− 0.61 to 0.69)	0.16 (− 0.73 to 0.40)
		Standard deviation		1.87	1.57
		Limits of agreement		− 3.63 to 3.71	− 3.26 to 2.92
	Accuracy	Above 95th percentile	Sensitivity	0.75	0.75
			Specificity	0.90	0.93
			PPV	0.50	0.60
			NPV	0.96	0.96
		Above 75th percentile	Sensitivity	0.70	0.60
			Specificity	0.91	0.91
			PPV	0.77	0.75
			NPV	0.88	0.84
		Above 40th percentile	Sensitivity	0.73	0.86
			Specificity	0.73	0.84
			PPV	0.68	0.81
			NPV	0.77	0.88
Sepsis	Linear regression analysis	Regression Coefficient (r)		0.87	0.78
		P value		0.02	0.19
		Slope		0.82	0.65
		Intercept		0.93	2.85
	Bland altman analysis	Bias (95% CI)		0.88 (0.43 to 1.34)	0.80 (0.22 to 1.39)
		Standard deviation		1.53	1.96
		Limits of agreement		− 2.11 to 3.88	− 3.04 to 4.65
	Accuracy	Above 95th percentile	Sensitivity	0.5	0.16
			Specificity	1.0	1.0
			PPV	1.0	1.0
			NPV	0.93	0.88
		Above 75th percentile	Sensitivity	0.71	0.71
			Specificity	1.00	1.00
			PPV	1.00	1.00
			NPV	0.95	0.95
		Above 40th percentile	Sensitivity	0.63	0.63
			Specificity	0.91	0.94
			PPV	0.70	0.70
			NPV	0.88	0.89
Birth asphyxia	Linear regression analysis	Regression Coefficient (r)		0.88	0.80
		P value		0.42	0.40
		Slope		0.69	0.58
		Intercept		2.78	3.94
	Bland altman analysis	Bias (95% CI)		0.37 (0.01 to 0.74)	0.39 (− 0.01 to 0.79)
		Standard deviation		1.76	1.93
		Limits of agreement		− 3.07 to − 2.44	− 3.40 to 4.18
	Accuracy	Above 95th percentile	Sensitivity	0.73	0.73
			Specificity	1.00	0.98
			PPV	1.00	0.91
			NPV	0.95	0.95
		Above 75th percentile	Sensitivity	0.87	0.77
			Specificity	0.91	0.96
			PPV	0.84	0.92
			NPV	0.93	0.89
		Above 40th percentile	Sensitivity	0.88	0.83
			Specificity	0.91	0.91
			PPV	0.90	0.90
			NPV	0.90	0.86

Back to article page

Table 3 The correlation between bilirubin values obtained from AJO-Neo and TSB along with predictive indices of AJO-Neo in neonates with AAP designated risk factors of hyperbilirubinemia.

Search

Quick links