Figure 2

Secondary endpoint: agreement between uCrCl and eGFR—modified bland–altman analysis. This modified analysis specifically takes into account the clustered nature of the data, i.e. that individual patients contribute more than one paired uCrCl/eGFR reading. Each hollow circle represents the paired within-patient eGFR/uCrCl measurements that were averaged within a patient, i.e. each hollow circle represents a single patient. Patients with only 1 paired measurement (i.e. only 1 cycle) were excluded from this analysis. The blue solid horizontal line represents the mean within-patient-averaged difference between uCrCl and eGFR. As this is above the orange dashed line of zero difference, uCrCl measurements are systematically higher than eGFR measurements in our study population. The dashed horizontal red lines represent the 95% limits of agreement (LoA). SD standard deviation, uCrCl urinary creatinine clearance, eGFR estimated glomerular filtration rate.