Figure 3
Differential neural activation after retrieval of an allocentric or egocentric memory from a familiar starting position. (A) Both allocentric (n = 15) and egocentric-trained mice (n = 12) progressively learned the task during training. Symbols represent the percentage of correct trials for each day of training (mean ± s.e.m.). (B) In the test trial from the familiar starting position on day 9, most allocentric-trained and egocentric-trained mice were able to correctly reach the goal box. Bars represent the percentage of mice that correctly (place or response) or incorrectly (wrong) located the reward at the test trial. (C) Counts of Zif268 positive cells from control mice trained in the presence of cues (n = 6) and allocentric-trained mice that performed correctly in the final test trial (n = 12). Bars represent mean ± s.e.m. *P < 0.05. (D) Counts of Zif268 stained nuclei in sections from control without cues (n = 6) and egocentric trained mice that correctly performed the final test trial (n = 8). Bars represent mean ± s.e.m. CA1 = CA1 subregion of the hippocampus; aDMS = anterior dorsomedial striatum; pDMS = posterior dorsomedial striatum; NacC = nucleus accumbens core; NacS = nucleus accumbens shell; PL = prelimbic cortex; IL = infralimbic cortex. (E–L) Representative images of retrieval induced Zif268 expression in the CA1 (E–H) and the posterior dorsamedial striatum (I–L) from controls trained in the presence of cues (E, I) or allocentric-trained mice (F, J), and from controls trained without cues (G, K) or egocentric-trained mice (H, L). Scale bar represents 100 μm.
