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Figure 1

From: HIV X4 Variants Increase Arachidonate 5-Lipoxygenase in the Pulmonary Microenvironment and are associated with Pulmonary Arterial Hypertension

Figure 1

HIV X4 viruses are over-represented in asymptomatic HIV patients with pulmonary hypertension. (a) We used translated sequences of the V3 region of the HIV-1 envelope gene to predict HIV tropism (co-receptor usage) by using the bioinformatics tool Geno2Pheno46. Asymptomatic patients were defined as CD4 counts > 200 cells/µl. Pulmonary hypertensive patients were defined as those with mean mPAP > 25 mm Hg by RHC or PASP > 25 mm Hg by echochardiography, while normotensive patients were defined as patients with mPAP < 24 mm Hg or PASP < 24 mm Hg. The percentages (%) on top of the bars indicate the percentage of patients harboring either HIV R5 or X4 variants. (b–d) Correlations between mPAP and CD4 counts (b), HIV viral loads (c), and duration of HIV infection (d). Each symbol represents a subject. Patients harboring HIV-R5 are indicated in blue circles; patients with HIV-X4 are indicated with yellow triangles. All CD4 counts < 200 cells/ul in the AIDS zone are shaded in gray (Panel B), while the mPAP within the PH zone are shaded in pink.

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