Table 1 Characteristics of study population by PAM expression group.

Characteristic	PAM expression group						All patients		p-value^a
Characteristic	Negative (0)		Low (1)		High (2 to 4)		All patients		p-value^a
Total	8 (7%)		27 (25%)		74 (68%)		109
Age at diagnosis, years; Median (IQR)	66 (60–70)		61 (54–73)		62 (50–70)		61 (52–70)		0.46
Sex, n (%)									0.41
F	5	62.5	18	66.7	39	52.7	62	56.9
M	3	37.5	9	33.3	35	47.3	47	43.1
Site, n (%)									0.06
Lung	4	50.0	5	18.5	21	28.4	30	27.5
Pancreas	0		6	22.2	18	24.3	24	22.0
Small bowel	0		5	18.5	19	25.7	24	22.0
Large bowel	2	25.0	6	22.2	11	14.9	19	17.4
Stomach	0		4	14.8	3	4.1	7	6.4
Other ^b	2	25.0	1	3.7	2	2.7	5	4.6
Functional status, n (%)									0.58^c
Functional	0		3	11.1	15	20.3	18	16.5
Non-functional	5	62.5	17	63.0	49	66.2	71	65.1
Unknown	3	37.5	7	25.9	10	13.5	20	18.4
WHO Grade									< 0.001^c
1 (Ki67 < 3)	1	12.5	12	44.4	57	77.0	70	64.2
2 (Ki67 3 to 20)	0		3	11.1	5	6.8	8	7.3
3 (Ki67 > 20)	5	62.5	7	25.9	1	1.4	13	11.9
Unknown	2	25.0	5	18.5	11	14.9	18	16.5
Tumor size (cm, mean (SD))	3.1 (0.8); n = 3		2.8 (2.0); n = 18		2.2 (2.1); n = 60		2.3 (2.0); n = 81		0.09
Stage at resection, n (%)									0.09^c
Unknown	2	25.0	4	14.8	9	12.2	15	13.7
1	2	25.0	8	29.6	30	40.5	40	36.7
2	0		3	11.1	14	18.9	17	15.6
3	3	37.5	2	7.4	9	12.2	14	12.8
4	1	12.5	10	37.0	12	16.2	23	21.1
Died	8	100.0	15	55.6	15	20.3	38	34.9	< 0.001
Time to death (months); Median (IQR)	11.3 (2.4–23.1)		29.4 (4.1–76.2)		61.7 (41.8–124.2)		48 (11.6–80.7)

^aBased Fisher’s exact or Kruskall–Wallis test; IQR: interquartile range; NE: not evaluable.
^bOther sites include the mediastinum, mesentery, bladder, ovary, and uterus.
^cAfter excluding unknown category.

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