Table 3 Cox proportional hazards for death: univariate, and adjusted for disease stage or WHO grade.

From: PAM staining intensity of primary neuroendocrine neoplasms is a potential prognostic biomarker

 

PAM < 1

PAM < 2

PAM < 3

Univariable

 HR (95% confidence interval)

11.20 (4.87–25.72)

4.14 (2.15–7.96)

3.31 (1.57–7.00)

 p-value

 < 0.0001

 < 0.0001

0.002

Adjusted for WHO grade

 HR (95% confidence interval)

1.00 (0.32–3.09)

1.77 (0.72–4.31)

1.96 (0.80–4.82)

 p-value

1.0

0.21

0.14

Adjusted for stage of disease

 HR (95% confidence interval)

13.76 (4.16–45.50)

3.49 (1.67–7.26)

3.69 (1.65–8.23)

 p-value

 < 0.0001

0.0008

0.001

  1. Reference group is PAM-positive for each Cox regression.