Scheme 1 | Scientific Reports

Scheme 1

From: Design, synthesis, structure, in vitro cytotoxic activity evaluation and docking studies on target enzyme GSK-3β of new indirubin-3ʹ-oxime derivatives

Scheme 1The alt text for this image may have been generated using AI.

Preparation of new derivatives 6a–p: Reagents and conditions: (i) propagyl bromide, DMF, K2CO3, KI, (1-butyl)triethylammonium, 48 h, rt, 59%; (ii) NH2OH.HCl, pyridine, 3 h, reflux, 79%; (iii) 5a–l, CuI, DMSO, 24 h, rt, 57–70%; (iv) 5m–p, NaN3, DMSO, K2CO3, CuI, 24 h, rt, 56–68%; (v) NH2OH·HCl, pyridine, 3 h, reflux, 93%.

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