Table 3 Univariate and multivariate Cox models for OS.
Variables | Uni HR | 95% CI | P value | Multi HR | 95% CI | P value |
|---|---|---|---|---|---|---|
Patient characteristic | ||||||
Age | ||||||
≤ 61 | 1 | |||||
> 60 | 0.72 | 0.52–1.00 | 0.046 | |||
Sex | ||||||
Male | 1 | 1 | ||||
Female | 0.57 | 0.34–0.94 | 0.027 | 0.48 | 0.27–0.88 | 0.016 |
Smoking index | ||||||
< 600 | 1 | |||||
≥ 600 | 1.42 | 1.03–1.96 | 0.034 | |||
ECOG performance status | ||||||
0–1 | 1 | |||||
2–3 | 1.38 | 0.51–3.74 | 0.53 | |||
History of alcohol consumption | ||||||
No | 1 | |||||
Yes | 1.37 | 0.99–1.89 | 0.06 | |||
Esophageal fistula | ||||||
No | 1 | 1 | ||||
Yes | 2.70 | 1.58–4.62 | < 0.001 | 2.5 | 1.35–4.64 | 0.004 |
Tumor characteristics | ||||||
Location | ||||||
Cervical | 1 | |||||
Upper thoracic | 3.64 | 0.50–26.6 | ||||
Middle thoracic | 3.73 | 0.52–27.0 | ||||
Lower thoracic | 3.76 | 0.52–27.1 | ||||
Synchronous | 8.34 | 1.05–66.0 | 0.12 | |||
Pathological type | ||||||
Squamous | 1 | |||||
Adenocarcinoma | 0.83 | 0.31–2.25 | ||||
Small cell | 1.08 | 0.60–1.96 | 0.90 | |||
Longitudinal length | 1.07 | 1.00–1.14 | 0.052 | |||
T stage | ||||||
T1–T3 | 1 | |||||
T4 | 1.11 | 0.76–1.62 | 0.59 | |||
N stage | ||||||
N0–N1 | 1 | |||||
N2–N3 | 1.25 | 0.91–1.72 | 0.18 | |||
Number of metastases | ||||||
1 | 1 | |||||
2 | 1.60 | 1.13–2.28 | ||||
3 | 1.29 | 0.71–2.34 | ||||
4 | 2.55 | 1.27–5.12 | ||||
5 | 2.82 | 0.88–9.05 | 0.013 | |||
Number of metastatic organs | ||||||
1 | 1 | 1 | ||||
2 | 1.59 | 1.13–2.25 | 1.74 | 1.18–2.56 | ||
3 | 2.11 | 1.02–4.35 | 0.009 | 2.00 | 1.25–7.21 | 0.001 |
Distant lymph node | ||||||
0–1 | 1 | |||||
> 1 | 1.54 | 1.09–2.17 | 0.014 | |||
Liver metastasis | ||||||
No | 1 | |||||
Yes | 0.96 | 0.55–1.68 | 0.89 | |||
Lung metastasis | ||||||
No | 1 | |||||
Yes | 1.66 | 1.04–2.66 | 0.035 | |||
Bone metastasis | ||||||
No | 1 | |||||
Yes | 1.14 | 0.58–2.24 | 0.70 | |||
Treatment characteristics | ||||||
Treatment protocol | ||||||
Single chemotherapy | 1 | |||||
Concurrent chemoradiotherapy | 0.53 | 0.34–0.83 | ||||
Sequential chemoradiotherapy | 0.50 | 0.34–0.74 | ||||
Single radiotherapy | 0.82 | 0.44–1.54 | ||||
Surgery + adjuvant therapy | 0.69 | 0.31–1.54 | 0.006 | |||
Local radiotherapy for EC | ||||||
No | 1 | 1 | ||||
Yes | 0.51 | 0.37–0.71 | < 0.001 | 0.15 | 0.23–0.93 | 0.041 |
Local treatment for metastases | ||||||
No | 1 | |||||
Partial metastases | 0.44 | 0.20–0.96 | ||||
All metastases | 0.52 | 0.37–0.72 | < 0.001 | |||
