Table 4 List of KEGG signaling pathways involving the five differentially expressed miRNAs predicted by their putative target genes.
From: Circulating miRNAs as molecular markers of occupational grain dust exposure
Pathway name | # predicted target genes | # genes | p value | FDR |
|---|---|---|---|---|
Upregulated miRNAs | ||||
hsa-miR-574-3p (n = 12) | ||||
Axon guidance | 97 | 129 | 1.85E−08 | 3.59E−06 |
Neurotrophin signaling pathway | 93 | 129 | 1.00E−06 | 1.90E−04 |
Endocytosis | 128 | 187 | 1.18E−06 | 2.24E−04 |
MAPK signaling pathway | 178 | 272 | 1.27E−06 | 2.41E−04 |
Pathways in cancer | 207 | 330 | 1.41E−05 | 2.60E−03 |
Long term potentiation | 54 | 71 | 1.49E−05 | 2.75E−03 |
ErbB signaling pathway | 65 | 89 | 2.11E−05 | 3.85E−03 |
Wnt signaling pathway | 102 | 152 | 4.98E−05 | 8.96E−03 |
T cell receptor signaling pathwaya | 76 | 110 | 1.03E−04 | 1.84E−02 |
Apoptosis | 62 | 87 | 1.09E−04 | 1.92E−02 |
Chemokine signaling pathway | 122 | 189 | 1.37E−04 | 2.43E−02 |
Non small cell lung cancer | 41 | 54 | 1.71E−04 | 3.01E−02 |
hsa-miR-124-3p (n = 13) | ||||
Pathways in cancer | 295 | 330 | 7.16E−08 | 1.39E−05 |
Adherens junction | 73 | 76 | 8.44E−08 | 1.63E−05 |
Axon guidance | 121 | 129 | 1.20E−06 | 2.32E−04 |
Endocytosis | 170 | 187 | 3.32E−06 | 6.34E−04 |
Fc gamma R mediated phagocytosisa | 92 | 97 | 5.87E−06 | 1.12E−03 |
Small cell lung cancer | 80 | 84 | 1.52E−05 | 2.84E−03 |
Gap junction | 85 | 90 | 2.29E−05 | 4.25E−03 |
Ubiquitin mediated proteolysis | 122 | 134 | 6.88E−05 | 1.21E−02 |
Regulation of actin cytoskeletona | 187 | 212 | 1.22E−04 | 2.10E−02 |
Neurotrophin signaling pathway | 117 | 129 | 1.49E−04 | 2.57E−02 |
Long term potentiation | 67 | 71 | 1.94E−04 | 3.32E−02 |
Wnt signaling pathway | 136 | 152 | 2.24E−04 | 3.81E−02 |
Chemokine signaling pathway | 167 | 189 | 2.25E−04 | 3.83E−02 |
Insulin signaling pathway | 125 | 139 | 2.34E−04 | 3.98E−02 |
hsa-miR-18a-5p (n = 4) | ||||
Pathways in cancer | 313 | 330 | 1.81E−05 | 3.51E−03 |
Chemokine signaling pathway | 182 | 189 | 6.00E−05 | 1.16E−02 |
Wnt signaling pathway | 147 | 152 | 1.46E−04 | 2.78E−02 |
Ubiquitin mediated proteolysis | 130 | 134 | 2.10E−04 | 3.99E−02 |
Downregulated miRNAs | ||||
hsa-miR-146a-5p (n = 11) | ||||
Pathways in cancer | 293 | 330 | 1.81E−13 | 3.51E−11 |
Adherens junction | 73 | 76 | 8.44E−08 | 1.63E−05 |
Wnt signaling pathway | 135 | 152 | 6.04E−07 | 1.16E−04 |
Small cell lung cancer | 78 | 84 | 2.28E−06 | 4.31E−04 |
MAPK signaling pathway | 228 | 272 | 4.98E−06 | 9.37E−04 |
Apoptosis | 79 | 87 | 1.97E−05 | 3.64E−03 |
ErbB signaling pathway | 80 | 89 | 4.46E−05 | 8.03E−03 |
Gap junction | 80 | 90 | 1.16E−04 | 2.03E−02 |
Ubiquitin mediated proteolysis | 115 | 134 | 1.49E−04 | 2.59E−02 |
Non-small cell lung cancer | 50 | 54 | 2.07E−04 | 3.57E−02 |
TGF beta signaling pathwaya | 76 | 86 | 2.70E−04 | 4.62E−02 |
hsa-miR-19b-3p (n = 7) | ||||
Pathways in cancer | 287 | 330 | 4.34E−09 | 8.43E−07 |
Wnt signaling pathway | 134 | 152 | 1.24E−05 | 2.36E−03 |
Endocytosis | 162 | 187 | 1.70E−05 | 3.23E−03 |
Ubiquitin mediated proteolysis | 118 | 134 | 4.60E−05 | 8.65E−03 |
Insulin signaling pathway | 121 | 139 | 1.22E−04 | 2.23E−02 |
Small cell lung cancer | 76 | 84 | 1.35E−04 | 2.45E−02 |
Adherens junction | 69 | 76 | 2.12E−04 | 3.79E−02 |
