Figure 4
From: The discovery of a new antibody for BRIL-fused GPCR structure determination
Electron density maps of the ligand and structural comparison of the ligand binding site (A) The ligand omitted mFo–DFc polder electron density (light blue mesh) of ergotamine (ERG) contoured at 3.0 σ. (B) The ligand omitted mFo–DFc polder electron density (light blue mesh) of s-Ang II contoured at 3.0 σ. (C) Comparison of ligand binding cavity of 5HT1B/ERG/SRP2070Fab (left) and 5HT1B/ERG (PDB ID: 4IAR) (right). ERG is shown as sticks. (D) Comparison of ligand bindin cavity of AT2R/s-Ang II/SRP2070Fab (left) and AT2R/s-Ang II (PDB ID: 5XJM) (right). s-Ang II is shown as sticks.
