Figure 1 | Scientific Reports

Figure 1

From: Analysis of tumor mutational burden: correlation of five large gene panels with whole exome sequencing

Figure 1

TMB values in mutations per MB of only coding non-synonymous (x-axis) and synonymous (y-axis) for bioinformatic pipelines that allowed for this differentiation. Panels: Illumina—TSO500; NEO—NEOplus v2 RUO TMB (NEO New Oncology); Custom Agilent custom—custom panel Agilent SureSelect XT HS; Exome tumor only—WES Agilent SureSelect XT HS Human All Exon v6 panel; Qiagen Mutect2—Qiagen TMB v3.0 (Qiagen) analyzed with Mutect2 in-house pipeline; Qiagen Genomics—Qiagen TMB v3.0 (Qiagen) analyzed with Qiagen Genomics Workbench 12.0.2.; Oncomine Tumor Mutation Load assay (Thermo Fisher Scientific) did not allow for differentiation of synonymous and non-synonymous variants.

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