Table 3 Factors affecting psycho-motor development.
From: The patterns of response of 11 regimens for infantile spasms
Variable | Psycho-motor prognosis | P value | OR (95% CI) | |
|---|---|---|---|---|
Poor prognosis (n = 277) | Good prognosis (n = 37) | |||
Sex (male:female) | 178:99 | 23:14 | 0.805 | – |
Age at onset, m | 3 (0–23.6) | 5.5 (0.7–14) | 0.632 | – |
Number of treatment regimens (Med (Min–Max)) | 4 (1–11) | 2 (1–9) | < 0.001 | 0.599 (0.470–0.764) |
Median time between onset and treatment initiation, m (Med (Min–Max)) | 1 (0–34) | 1 (0–10) | 0.602 | – |
Patients who received one of the first-line therapies as first or second regimen (%) | 144 (52.0) | 27 (73.0) | 0.019 | 2.494 (1.163–5.348) |
Patients who received first-line therapies (%) | 234 (84.5) | 35 (94.6) | 0.099 | – |
Median time between onset of symptoms and first-line therapy initiation, median (Min–Max) | 3.5 (0–89.5) | 2 (0–27) | 0.116 | – |
Seizure freedom (%) | 152 (54.9) | 37 (100) | < 0.001 | – |
Maximum control time, y (Med (Min–Max)) | 2.67 (1–7.83) | 3.58 (1.5–10) | < 0.001 | 1.482 (1.219–1.803) |
Age at seizure control, y (Med (Min–Max)) | 1.33 (0.33–8.92) | 0.75 (0.33–6.75) | 0.068 | – |
Seizures controlled by first-line therapies (%) | 91 (59.9) | 30 (81.1) | 0.019 | 2.873 (1.186–6.956) |
