Figure 6 | Scientific Reports

Figure 6

From: Effect of intravenous immunoglobulin (IVIg) on primate complement-dependent cytotoxicity of genetically engineered pig cells: relevance to clinical xenotransplantation

Figure 6

IgG and IgM binding to pRBCs after IVIg (FLEBOGAMMA) (2 g/kg) administration to a naive baboon. (A) In a naïve baboon, IgG binding to WT pRBCs was significantly increased after i.v. administration of 2 g/kg IVIg. IgM binding to WT pRBCs was significantly increased 1 and 6 days after IVIg. There was no significant difference in IgG or IgM binding to (B) GTKO, and (C) TKO pRBCs after i.v. administration of 2 g/kg IVIg. See “Materials and methods” section [Binding of anti-pig IgG and IgM, hemolytic assay, and serum complement levels in a baboon administered 2 g/kg of IVIg (FLEBOGAMMA)]. Heat-inactivated serum was used in this assay. On the y axis, the dotted line represents the lowest measurable limit of binding, below which there is considered to be no binding (relative GM: IgM 1.2, IgG 1.1). Results are expressed as mean + /− SD (*p < 0.05, **p < 0.01).

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