Figure 8 | Scientific Reports

Figure 8

From: Effect of intravenous immunoglobulin (IVIg) on primate complement-dependent cytotoxicity of genetically engineered pig cells: relevance to clinical xenotransplantation

Figure 8

Serum cytotoxicity of baboon serum against WT pRBCs after i.v. administration of IVIg (FLEBOGAMMA) (2 g/kg). (A) The cytotoxicity of baboon serum (final concentration 50%) immediately (day 0) and on day 1 after IVIg (2 mg/kg) against WT pRBCs was significantly decreased. The dotted line represents cut-off value (7%), below which cytotoxicity is considered negative. See “Materials and methods” section [Binding of anti-pig IgG and IgM, hemolytic assay, and serum complement levels in a baboon administered 2 g/kg of IVIg (FLEBOGAMMA)]. Non-heat-inactivated serum (i.e. complement activity +) was used in this assay. Results are expressed as mean + /− SD (*p < 0.05, **p < 0.01). (B) Immediately after IVIg, lysis of WT pRBCs was completely inhibited.

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