Table 1 Top hits for drivers of centrosome amplification in human cancer.
Centrosome gene | Known functions (especially centrosome-related functions) | Hypothesis |
|---|---|---|
CEP19 | Ciliation; microtubule anchoring to the centrosome; inactivation results in morbid obesity | Gain of function causes CA |
CEP72 | Centriolar satellite component; recruit key centrosomal proteins to centrosome; microtubule nucleation; BRCA1 interactor; overexpression increases CIN, aneuploidy, lagging chromosomes | Gain of function causes CA |
CEP76 | Limits centriole duplication; depletion drives aberrant amplification of centrioles | Loss of function causes CA |
CTNNB1 | Wnt signaling pathway; negative regulator of centrosome cohesion; overexpression of stabilized mutant increases centrosomes | Gain of function causes CA |
MCPH1 | Neurogenesis; chromosome condensation; DNA damage response; restrains DNA damage-induced CA; germline mutations cause microcephaly | Loss of function causes CA |
NEURL4 | Interacts with CP110 (important for limiting centriole elongation) | Loss of function causes CA |
NDRG1 | Cell trafficking; regulates centrosome number | Gain of function causes CA |
NPM1 | Ribosome biogenesis; depleting NPM1 results in CA | Loss of function causes CA |
PTK2 | Cell migration, adhesion, spreading, actin reorganization, focal adhesion formation, proliferation, apoptosis | Gain of function causes CA |
SPATC1 | Proximal centriole marker | Gain of function causes CA |
TBCCD1 | Localizes to a region sub-proximal to centrioles; mutant cells have variable numbers of centrioles and centriole positioning defects required for mother-daughter centriole linkage and mitotic spindle orientation; migration | Gain of function causes CA |
