Figure 10 | Scientific Reports

Figure 10

From: The food contaminant deoxynivalenol provokes metabolic impairments resulting in non-alcoholic fatty liver (NAFL) in mice

Figure 10

Schematic representation of the signaling events that might underlie the toxic effects elicited by DON intoxication on energy metabolism and liver steatosis. In an initial phase (3 h), DON induced a hormonal storm (insulin, adrenaline and corticosterone release) associated with a rise in liver lipogenesis and adipose tissue lipolysis. Moreover, inflammation and ER stress were observed within the liver and adipose tissues. A second phase intervened between 6 and 12 h where the increased blood NEFAs and TG resulting from adipose lipolysis and the drop in liver beta oxidation and lipolysis drive liver steatosis.

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