Table 1 Measured folding free energy of AR_LBD WT and mutants.

From: Computational analysis of androgen receptor (AR) variants to decipher the relationship between protein stability and related-diseases

AR-LBD

Disease

m value

C1/2[GdmHCl]

ΔG0

∆∆G (FoldX)

∆∆G (experiments)

Solubility

WT

Health

1.7 ± 0.1

3.0

− 5.3 ± 0.1

0

0

+++++

I738T

PAIS

1.3 ± 0.1

2.2

− 3.0 ± 0.2

1.4

2.3

+++

C807Y

PAIS

1.1 ± 0.2

2.0

− 2.2 ± 0.1

6.2

3.1

+

W752R

CAIS

0.9 ± 0.1

1.9

− 1.7 ± 0.3

3.6

3.6

+

L813F

CAIS

0.6 ± 0.3

2.2

− 1.5 ± 0.1

6.3

3.8

+

  1. Measured C1/2[GdmHCl], folding free energy (ΔG0), standard error of folding free energy, change of folding free energy (∆∆G), m value, and standard error of m value of AR_LBD WT and mutants.
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