Figure 6 | Scientific Reports

Figure 6

From: Pro-angiogenic scaffold-free Bio three-dimensional conduit developed from human induced pluripotent stem cell-derived mesenchymal stem cells promotes peripheral nerve regeneration

Figure 6

The Bio 3D conduit promotes neurogenesis and angiogenesis. (A) Heatmap illustrating the expression of neurogenesis and angiogenesis related genes in iPSCs, iNCCs, cells in each Bio 3D conduit-generating step, and BM-MSCs. By convention, highly expressed genes are shown in red and lowly expressed genes are shown in blue. iMSCs in each Bio 3D conduit-generating step included a large subset of upregulated neurogenesis (left) and angiogenesis (right) related genes. Gene names and values used to obtain the heatmap are shown in Table S2. (B) The mRNA expression of neurogenesis and angiogenesis genes was confirmed by RT-qPCR. **P < 0.01, by Dunnett’s multiple comparisons t test compared with iPSCs.

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