Figure 4
From: A small library of chalcones induce liver cancer cell death through Akt phosphorylation inhibition
Proteins targeted by the compounds. Human liver cancer cells (Mahlavu) were treated with the IC50 concentrations of the selected compounds or DMSO control for 24 h. (A) Western blot analysis showed that Akt protein is inhibited in liver cancer cells treated with the compounds resulting in alterations of p21 and NFkB proteins. (B–D) Quantification of the results using ImageJ software. (E) Schematic representation of the molecular mechanism of action of the compounds. Blocked signaling is crossed.
