Table 1 IC50 (\(\upmu \hbox {M}\)) values of the compounds.
From: A small library of chalcones induce liver cancer cell death through Akt phosphorylation inhibition
Huh7 | HepG2 | Hep3B | Mahlavu | FOCUS | SNU475 | DPSC | |
|---|---|---|---|---|---|---|---|
1 | 1.3 | 4.2 | 6.2 | 2.2 | 4.9 | 3 | NI |
2 | 4.1 | 5.8 | 5.6 | 5.1 | 11.4 | 9.8 | 28.7 |
3 | 6.4 | 7.6 | 18 | 9.4 | 20 | 13.1 | NI |
4 | 44.4 | 51.6 | NI* | 24.8 | NI | 23.8 | NI |
5 | 3 | 9.1 | 8.5 | 9.2 | 5.4 | 14.5 | NI |
6 | 6.4 | 7.6 | 7.8 | 6.3 | 6.5 | 10 | NI |
7 | 44.9 | 58.9 | 47.5 | 31.1 | NI | NI | NI |
8 | 17.9 | 26 | 22.1 | 17.3 | 21.5 | 21.6 | NI |
9 | 5.3 | 7.3 | 7.3 | 6.3 | 3.3 | 5 | 25.7 |
10 | 11.9 | 13.9 | 16.5 | 14.6 | 15.9 | 20 | NI |
11 | 4.3 | 6.5 | 5.9 | 5.3 | 3.1 | 9 | 19.1 |
Quercetin | 12.5 | 8.4 | 21.8 | 11.3 | 17.9 | 11.6 | 21.2 |
Papaverine hydrochloride | 8.5 | 4.9 | 20.4 | 52.3 | 1.7 | 17.8 | NI |
Catechin hydrate | NI | NI | NI | NI | NI | NI | NI |
Sorafenib | 1.3 | 5.6 | NA | 7.9 | NA | 7.5 | 7.1 |
5-Fluorouracil | 30.7 | 5 | 15.2 | 10 | 7.7 | NA | 23.7 |
