Figure 1 | Scientific Reports

Figure 1

From: Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib

Figure 1

Oxygen consumption rate is significantly higher than extracellular acidification rate in OAC treatment-naïve biopsies. OCR, a measure of oxidative phosphorylation and ECAR, a measure of glycolysis were assessed in real-time in OAC treatment-naïve biopsies using the Seahorse Biosciences XFe24 Analyser. (A) Basal OCR and ECAR rates in OAC pre-treatment biopsies, (n = 17). (B) OCR is significantly elevated in OAC treatment-naïve biopsies, (n = 17), Wilcoxon signed rank test, ***p < 0.001. (C) Relative metabolic ratio OCR:ECAR compared to ECAR:OCR in OAC treatment naïve biopsies (n = 17), paired t-test, **p < 0.01. Data expressed as + SEM.

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