Figure 3 | Scientific Reports

Figure 3

From: Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib

Figure 3

OAC treatment-naïve patient biopsies have an altered metabolic phenotype under hypoxic conditions (0.5% O2). OCR and ECAR were measured in real-time in male OAC treatment biopsies using Seahorse Technology. (A) Basal OCR and ECAR at baseline and post 6 h incubation under hypoxia 0.5% O2, (n = 7). (B) OCR:ECAR ratio of OAC pre-treatment biopsies cultured under normoxic and then hypoxic conditions, (n = 7). (C) ECAR:OCR ratio of OAC treatment-naïve biopsies cultured under normoxic and then hypoxic conditions, (n = 7). Wilcoxon signed rank t-test, *p < 0.05. Data expressed as + SEM.

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