Table 1 Correlation of Metabolic rate with protein secretions in matched OAC treatment-naïve biopsies.

From: Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib

Correlation with oxygen consumption rate

Factor

R value

P value

Significance

N

ECAR

0.8505

 < 0.0001

***

17

VEGF-A

0.7091

0.0268

*

10

IL-1RA

0.7939

0.0088

**

10

TSLP

0.6727

0.0390

*

10

  1. The protein secretions of 54 mediators analysed by multiplex ELISA were correlated with real-time metabolic rate readouts of OCR of matched patient biopsies. (A) OCR was significantly correlated with the rate of ECAR and the secreted levels of 3 of 54 proteins including VEGF-A, IL-1RA and TSLP in matched OAC treatment-naïve biopsies. Secretions from explant tissue and metabolic rate were normalised to protein content. Spearman correlations; Spearman r 0.4–0.59 moderate, 0.6–0.79 strong, 0.8–1.0 very strong; *p < 0.05, **p < 0.01, ***p < 0.0001.
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