Table 2 Correlation of metabolic rate with protein secretions in matched OAC treatment-naïve biopsies.

From: Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib

Correlation with extracellular acidification rate

Factor

R value

P value

Significance

N

OCR

0.8505

 < 0.0001

***

17

VEGF-A

0.8303

0.0047

**

10

IL-1RA

0.7455

0.0174

*

10

MIP-3α

0.6606

0.0438

*

10

TNF-α

0.6606

0.0438

*

10

IL-13

0.7212

0.0234

*

10

TSLP

0.7697

0.0126

*

10

  1. The protein secretions of 54 mediators analysed by multiplex ELISA were correlated with real-time metabolic rate readouts of ECAR of matched patient biopsies. ECAR, a measure of glycolysis, was significantly correlated with the rate of OCR and the secreted levels of 6 of 54 proteins including VEGF-A, IL-1RA, MIP-3α, TNF-α, IL-13 and TSLP in matched OAC treatment-naïve biopsies. Secretions from explant tissue and metabolic rate were normalised to protein content. Spearman correlations; Spearman r 0.4–0.59 moderate, 0.6–0.79 strong, 0.8–1.0 very strong; *p < 0.05, **p < 0.01, ***p < 0.0001.
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