Table 1 Estimates of the effect of genetically influenced longer telomere length on nine blood-cell traits.

From: A Mendelian randomization study of telomere length and blood-cell traits

Test

Strength

IVW analysis

Weighted median

Weighted mode

MR-Egger

Outcome (N)

No. SNPs

R2

F

β (95% CI)

P

β (95% CI)

P

β (95% CI)

P

β (95% CI)

I2 statistic

P

RBC (172,952)

0.01

13

0.09 (0.04, 0.14)

2.4Eāˆ’04*

0.09 (0.03, 0.15)

1.9Eāˆ’03

0.09 (0.03, 0.16)

3.2Eāˆ’02

0.11 (0.00, 0.23)

1.1Eāˆ’01

SNPs = 7

Ā Ā Ā Ā Ā Ā Ā Ā 

I2 = 86

Ā 

WBC (172,435)

0.01

15

0.06 (0.02, 0.11)

4.2Eāˆ’03*

0.07 (0.02, 0.12)

7.5Eāˆ’03

0.07 (0.02, 0.12)

7.5Eāˆ’02

0.12 (0.01, 0.23)

2.8Eāˆ’02

SNPs = 8

Ā Ā Ā Ā Ā Ā Ā Ā 

I2 = 87

Ā 

Ret. (170,641)

0.02

17

0.04 (0.00, 0.08)

3.3Eāˆ’02

0.04 (āˆ’ā€‰0.01, 0.09)

1.2Eāˆ’01

0.03 (āˆ’ā€‰0.02, 0.09)

2.7Eāˆ’01

āˆ’ā€‰0.04 (āˆ’ā€‰0.15, 0.06)

4.6Eāˆ’01

SNPs = 9

Ā Ā Ā Ā Ā Ā Ā Ā 

I2 = 87

Ā 

MCH (172,332)

0.01

13

āˆ’ā€‰0.12( āˆ’ā€‰0.18, āˆ’ā€‰0.07)

7.5Eāˆ’06*

āˆ’ā€‰0.10 (āˆ’ā€‰0.17, āˆ’ā€‰0.03)

7.1Eāˆ’03

āˆ’ā€‰0.13( āˆ’ā€‰0.20, āˆ’ā€‰0.05)

1.9Eāˆ’02

āˆ’ā€‰0.17 (āˆ’ā€‰0.29, āˆ’ā€‰0.05)

4.6Eāˆ’02

SNPs = 6

Ā Ā Ā Ā Ā Ā Ā Ā 

I2 = 89

Ā 

MCV(172,433)

0.01

15

āˆ’ā€‰0.13 (āˆ’ā€‰0.18, āˆ’ā€‰0.08)

7.1Eāˆ’07*

āˆ’ā€‰0.14 (āˆ’ā€‰0.21, āˆ’ā€‰0.07)

4.2Eāˆ’05

āˆ’ā€‰0.14 (āˆ’ā€‰0.20, āˆ’ā€‰0.08)

6.7Eāˆ’03

āˆ’ā€‰0.15 (āˆ’ā€‰0.27, āˆ’ā€‰0.03)

7.4Eāˆ’02

SNPs = 6

Ā Ā Ā Ā Ā Ā Ā Ā 

I2 = 89

Ā 

MCHC (172,851)

0.01

15

āˆ’ā€‰0.02 (āˆ’ā€‰0.06, 0.02)

4.1Eāˆ’01

0.00 (āˆ’ā€‰0.05, 0.06)

9.0Eāˆ’01

0.01 (āˆ’ā€‰0.05, 0.08)

7.3Eāˆ’01

āˆ’ā€‰0.05(āˆ’ā€‰0.15, 0.05)

3.6Eāˆ’01

SNPS = 8

Ā Ā Ā Ā Ā Ā Ā Ā 

I2 = 87

Ā 

RDW(171,529)

0.02

16

0.02 (āˆ’ā€‰0.02, 0.06)

3.5Eāˆ’01

0.01 (āˆ’ā€‰0.04, 0.06)

6.6Eāˆ’01

0.02 (āˆ’ā€‰0.04, 0.07)

6.1Eāˆ’01

0.05 (āˆ’ā€‰0.06, 0.17)

4.1Eāˆ’01

SNPs = 10

Ā Ā Ā Ā Ā Ā Ā Ā 

I2 = 84

Ā 

Hct (173,039)

0.01

14

0.03 (āˆ’ā€‰0.02, 0.08)

2.2Eāˆ’01

0.01 (āˆ’ā€‰0.04, 0.07)

6.4Eāˆ’01

0.01 (āˆ’ā€‰0.04, 0.07)

6.6Eāˆ’01

0.02 (āˆ’ā€‰0.10, 0.13)

8.0Eāˆ’01

SNPs = 7

Ā Ā Ā Ā Ā Ā Ā Ā 

I2 = 86

Ā 

Hgb (172,925)

0.02

17

0.04 (0.00, 0.08)

8.3Eāˆ’02

0.04 (āˆ’ā€‰0.01, 0.10)

1.0Eāˆ’01

0.04 (āˆ’ā€‰0.02, 0.10)

2.6Eāˆ’01

0.01 (āˆ’ā€‰0.11, 0.12)

8.9Eāˆ’01

SNPs = 8

Ā Ā Ā Ā Ā Ā Ā Ā 

I2 = 85

Ā 
  1. β beta estimate, CI confidence interval, P P value; *indicates below Bonferroni threshold (P < 0.006); RBC red blood cell, WBC white blood cell, ret reticulocyte, MCH mean corpuscular hemoglobin, MCV mean cell volume, MCHC mean corpuscular hemoglobin concentration, RDW red cell distribution width, Hct hematocrit, Hgb hemoglobin.