Table 1 Estimates of the effect of genetically influenced longer telomere length on nine blood-cell traits.
From: A Mendelian randomization study of telomere length and blood-cell traits
Test | Strength | IVW analysis | Weighted median | Weighted mode | MR-Egger | |||||
|---|---|---|---|---|---|---|---|---|---|---|
Outcome (N) No. SNPs | R2 | F | β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | β (95% CI) I2 statistic | P |
RBC (172,952) | 0.01 | 13 | 0.09 (0.04, 0.14) | 2.4Eā04* | 0.09 (0.03, 0.15) | 1.9Eā03 | 0.09 (0.03, 0.16) | 3.2Eā02 | 0.11 (0.00, 0.23) | 1.1Eā01 |
SNPsā=ā7 | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | I2ā=ā86 | Ā |
WBC (172,435) | 0.01 | 15 | 0.06 (0.02, 0.11) | 4.2Eā03* | 0.07 (0.02, 0.12) | 7.5Eā03 | 0.07 (0.02, 0.12) | 7.5Eā02 | 0.12 (0.01, 0.23) | 2.8Eā02 |
SNPsā=ā8 | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | I2ā=ā87 | Ā |
Ret. (170,641) | 0.02 | 17 | 0.04 (0.00, 0.08) | 3.3Eā02 | 0.04 (āā0.01, 0.09) | 1.2Eā01 | 0.03 (āā0.02, 0.09) | 2.7Eā01 | āā0.04 (āā0.15, 0.06) | 4.6Eā01 |
SNPsā=ā9 | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | I2ā=ā87 | Ā |
MCH (172,332) | 0.01 | 13 | āā0.12( āā0.18, āā0.07) | 7.5Eā06* | āā0.10 (āā0.17, āā0.03) | 7.1Eā03 | āā0.13( āā0.20, āā0.05) | 1.9Eā02 | āā0.17 (āā0.29, āā0.05) | 4.6Eā02 |
SNPsā=ā6 | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | I2ā=ā89 | Ā |
MCV(172,433) | 0.01 | 15 | āā0.13 (āā0.18, āā0.08) | 7.1Eā07* | āā0.14 (āā0.21, āā0.07) | 4.2Eā05 | āā0.14 (āā0.20, āā0.08) | 6.7Eā03 | āā0.15 (āā0.27, āā0.03) | 7.4Eā02 |
SNPsā=ā6 | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | I2ā=ā89 | Ā |
MCHC (172,851) | 0.01 | 15 | āā0.02 (āā0.06, 0.02) | 4.1Eā01 | 0.00 (āā0.05, 0.06) | 9.0Eā01 | 0.01 (āā0.05, 0.08) | 7.3Eā01 | āā0.05(āā0.15, 0.05) | 3.6Eā01 |
SNPSā=ā8 | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | I2ā=ā87 | Ā |
RDW(171,529) | 0.02 | 16 | 0.02 (āā0.02, 0.06) | 3.5Eā01 | 0.01 (āā0.04, 0.06) | 6.6Eā01 | 0.02 (āā0.04, 0.07) | 6.1Eā01 | 0.05 (āā0.06, 0.17) | 4.1Eā01 |
SNPsā=ā10 | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | I2ā=ā84 | Ā |
Hct (173,039) | 0.01 | 14 | 0.03 (āā0.02, 0.08) | 2.2Eā01 | 0.01 (āā0.04, 0.07) | 6.4Eā01 | 0.01 (āā0.04, 0.07) | 6.6Eā01 | 0.02 (āā0.10, 0.13) | 8.0Eā01 |
SNPsā=ā7 | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | I2ā=ā86 | Ā |
Hgb (172,925) | 0.02 | 17 | 0.04 (0.00, 0.08) | 8.3Eā02 | 0.04 (āā0.01, 0.10) | 1.0Eā01 | 0.04 (āā0.02, 0.10) | 2.6Eā01 | 0.01 (āā0.11, 0.12) | 8.9Eā01 |
SNPsā=ā8 | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | I2ā=ā85 | Ā |