Figure 1

Progranulin expression in the heart after myocardial infarction in mice. (A) Representative images show progranulin (58–68 kD) in the ischemic area 6 h and 1, 3, 5, and 7 days after permanent occlusion of left coronary artery (LCA) by Western blotting. (B) Quantitative analysis of progranulin normalized to GAPDH in the ischemic area. (C) Representative images show progranulin (58–68 kD) in non-ischemic area 6 h and 1, 3, 5, and 7 days after permanent occlusion of LCA by Western blotting. (D) Quantitative analysis of progranulin normalized to GAPDH in non-ischemic area. The expression of progranulin increased in the ischemic area 1, 3, and 5 days after permanent occlusion of LCA. Data are the means ± SEM. (n = 5–7) ^*p < 0.05, ^**p < 0.01 versus sham-operated group (one-way ANOVA followed by Dunnett's test).