Table 1 Clinical characteristics of the study population.

From: Maternal total cell-free DNA in preeclampsia with and without intrauterine growth restriction

Characteristics

Controls

PE

GH

P†

Pa‡

Pb‡

Second trimester

(n = 78)

(n = 29)

(n = 12)

   

Maternal age (years)

33.5 ± 3.5

35.5 ± 3.7

36.3 ± 4.3

0.007

0.028

0.029

Nulliparity

9 (29.0%)

8 (27.6%)

4 (33.3%)

0.93

1.00

1.00

GA at sampling (weeks)

21.6 ± 4.2

20.0 ± 3.9

20.0 ± 4.2

0.13

0.13

0.38

BMI at sampling (kg/m2)

22.6 ± 2.4

24.2 ± 3.2

26.8 ± 6.0

 < .0001

0.03

 < .0001

GA at delivery (weeks)

39.5 ± 1.0

37.8 ± 2.6

38.8 ± 1.4

0.003

0.001

0.50

Birthweight (g)

3,245 ± 336

2,785 ± 767

2,961 ± 282

0.008

0.004

0.24

Third trimester

(n = 58)

(n = 20)

(n = 7)

   

Maternal age (years)

34.2 ± 3.5

34.5 ± 3.4

36.0 ± 2.6

0.41

0.93

0.33

Nulliparity

10 (52.6%)

9 (45.0%)

2 (28.6%)

0.61

0.63

0.63

GA at sampling (weeks)

36.8 ± 0.7

36.4 ± 2.1

37.5 ± 1.5

0.12

0.37

0.30

BMI at sampling (kg/m2)

25.6 ± 2.6

28.2 ± 3.5

29.6 ± 4.1

 < .0001

0.002

0.002

GA at delivery (weeks)

39.7 ± 1.1

37.3 ± 2.2

39.3 ± 1.1

 < .001

 < .0001

0.81

Birthweight (g)

3,281 ± 360

2,668 ± 610

3,122 ± 337

0.001

 < .001

0.68

  1. Data are given as mean ± SD or number (%).
  2. Pa, PE versus controls; Pb, GH versus controls.
  3. BMI body mass index, GA gestational age, GH gestational hypertension, PE preeclampsia.
  4. †P value by Pearson’s chi-square test, Fisher's exact test or ANOVA as appropriate.
  5. ‡Adjusted P value by Pearson’s chi-square test, Fisher's exact test with step-up Bonferroni method or Dunnett multiple comparisons test.
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