Table 3 GWAS data sets used in our MR analysis in the present study.

From: Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis

Traits

Pop

k1/k0

N (case/control)

Data source

ALS

EUR

 

80,610 (20,806/59,804)

AVS20

HDL

EUR

85/87

93,561

GLGC61

LDL

EUR

78/78

89,138

GLGC61

TC

EUR

86/86

93,845

GLGC61

TG

EUR

53/54

90,263

GLGC61

LTL

EUR

7/7

37,684

ENGAGE21

FTD

EUR

 

12,928 (3,526/9,402)

IFGC36

HDL

EUR

79/87

93,561

GLGC61

LDL

EUR

66/78

89,138

GLGC61

TC

EUR

76/86

93,845

GLGC61

TG

EUR

47/54

90,263

GLGC61

LTL

EUR

6/7

37,684

ENGAGE21

ALS

Asian

 

4,084 (1,234/2,850)

Benyamin37

HDL

Asian

30/31

70,657

Kanai89

LDL

Asian

21/22

72,866

Kanai89

TC

Asian

31/32

128,305

Kanai89

TG

Asian

26/26

105,597

Kanai89

LTL

Asian

8/10

23,096

SCHS22

  1. Here k1 is the final number of instruments employed in the analysis while k0 is the number of candidate instruments.
  2. ALS amyotrophic lateral sclerosis, FTD frontotemporal dementia, HDL high density lipoprotein, LDL low density lipoprotein, TC total cholesterol, TG triglycerides, LTL leukocyte telomere length, Pop population, EUR European, AVS the ALS Variant Server, IFGC International FTD-Genomics Consortium, GLGC Global Lipids Genetics Consortium, ENGAGE European Network for Genetic and Genomic Epidemiology, SCHS Singapore Chinese Health Study.
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