Table 4 Association of LTL with the risk of ALS or FTD in the European and Asian populations.

From: Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis

Method

ALS-european

FTD-european

ALS-asian

OR (95% CI, p)

OR (95% CI, p)

OR (95% CI, p)

IVW-random

1.10 (0.92–1.32, 0.284)

0.81 (0.44–1.48, 0.498)

0.75 (0.53–1.07, 0.116)

IVW-fixed

1.10 (0.93–1.31, 0.274)

0.81 (0.44–1.48, 0.498)

0.75 (0.53–1.07, 0.116)

MR-Egger

1.02 (0.32–3.29, 0.964)

0.40 (0.01–14.71, 0.516)

0.61 (0.24–1.56, 0.241)

Weighted Median

1.06 (0.85–1.32, 0.624)

0.73 (0.35–1.52, 0.400)

0.67 (0.43–1.05, 0.082)

Likelihood

1.10 (0.92–1.32, 0.290)

0.81 (0.44–1.48, 0.496)

0.75 (0.53–1.07, 0.115)

GSMR

1.10 (0.93–1.31, 0.274)

0.81 (0.44–1.48, 0.498)

0.73 (0.51–1.05, 0.086)a

  1. The intercept of the MR-Egger regression is 0.006 (95% CI − 0.079–0.090, p = 0.872), 0.055 (95% CI − 0.214–0.323, p = 0.601) or 0.026 (95% CI − 0.076–0.128, p = 0.552), respectively.
  2. aSeven instruments were finally employed because the genotype of rs41309367 on gene RTEL1 was missing in the 1,000 Genomes Project.
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