Table 2 Estimated genetic effects of highly significant loci for body weight in the base and conditional models.

From: Conditional and unconditional genome-wide association study reveal complicate genetic architecture of human body weight and impacts of smoking

Chr_SNP_Allele (major/minor)

Gene

Effect

Estimate

SE

–LogPEW

\(h^{2}\) (%)

Smoke

1_rs1415210_A/T

CRB1

a

4.13

0.42

22.12

0.62

√

de1

3.46

0.73

5.69

0.43

√

2_rs11684785_T/C

TMEM163

d

6.26

0.51

33.57

1.41

 × 

6_rs2504934_G/A

SLC22A3

d

4.22

0.63

10.81

0.64

 × 

de1

– 7.59

0.86

17.98

2.09

 × 

de3

22.27

1.52

47.43

17.93

 × 

de4

– 13.67

1.14

32.31

6.76

 × 

7_rs620175_T/C

SDK1

ae2

–  5.26

0.91

8.05

1.00

√

ae3

8.74

0.94

19.70

2.76

 × 

ae4

– 5.68

0.85

10.73

1.17

 × 

7_rs9639575_T/G

CREB5

a

– 5.12

0.41

35.65

0.95

 × 

de4

– 4.59

1.03

5.05

0.76

√

10_rs1277840_C/T

CACNB2

de3

– 5.11

0.96

7.05

0.95

√

14_rs17094894_C/T

175 kb 3′ of VRK1

d

6.94

0.92

13.19

1.74

√

de4

– 10.54

1.37

13.84

4.02

 × 

1_rs1415210_A/T × 6_rs2504934_G/A

CRB1 × SLC22A3

ad

–5.87

0.83

11.69

1.25

 × 

ade1

5.23

1.18

5.03

0.99

√

ade3

– 9.51

1.73

7.43

3.27

 × 

2_rs11684785_T/C × 7_rs620175_T/C

TMEM163 × SDK1

da

– 4.02

0.62

10.03

0.58

 × 

dae1

– 6.92

0.91

13.62

1.73

 × 

dd

– 7.74

0.90

16.94

2.16

 × 

2_rs11684785_T/C × 14_rs17094894_C/T

TMEM163 × 175 kb 3′ of VRK1

aa

4.56

0.45

23.39

0.75

 × 

dae1

4.51

0.76

8.55

0.73

√

6_rs2504934_G/A × 7_rs620175_T/C

SLC22A3 × SDK1

aa

– 6.05

0.46

38.26

1.32

 × 

aae1

5.28

0.75

11.55

1.01

 × 

aae2

– 4.17

0.92

5.26

0.63

 × 

aae3

– 7.71

1.06

12.52

2.15

 × 

aae4

7.81

1.06

12.70

2.20

 × 

da

3.45

0.77

5.17

0.43

√

7_rs620175_T/C × 7_rs9639575_T/G

SDK1 × CREB5

aa

2.43

0.48

6.32

0.21

√

7_rs620175_T/C × 10_rs1277840_C/T

SDK1 × CACNB2

ad

3.03

0.62

6.00

0.33

√

dd

6.46

0.81

14.92

1.51

 × 

  1. Model: Smoke = model setting smoking as a cofactor. √: effect caused by smoking. ×: effect not affected by smoking.
  2. Genetic effect: a = additive effect, d = dominance effect, aa = additive × additive epistasis effect, ad = additive × dominance epistasis effect, da = dominance × additive epistasis effect, dd = dominance × dominance epistasis effect, ae2 = C-A specific additive effect, ae3 = A-A specific additive effect, ae4 = H-A specific additive effect, de1 = E-A specific dominance effect, de3= A-A specific dominance effect, de4= H-A specific dominance effect, aae1 = E-A specific additive × additive epistasis effect, aae2 = C-A specific additive × additive epistasis effect, aae3 = A-A specific additive × additive epistasis effect, aae4 = H-A specific additive × additive epistasis effect, ade1 = E-A specific additive × dominance epistasis effect, ade3 = A-A specific additive × dominance epistasis effect, dae1 = E-A specific dominance × additive epistasis effect. − LogPEW = minus log10(experiment-wise P-value). h2 = heritability.
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