Figure 6
From: Trisk 95 as a novel skin mirror for normal and diabetic systemic glucose level
Proposed model for the mechanism by which high glucose triggers calcium uptake in the ER and mitochondria via Trisk 95. Under normal conditions (low glucose) no binding occurs between Trisk 95 and RYR and the calcium level in the ER is thus maintained via constant exchange with the cytosol. The calcium level is important for the functioning of the mitochondria (a). In the presence of high glucose Trisk 95 is overexpressed at transcriptional and then protein level, leading to its binding to the RYR channel and resulting in the closure of the latter. As a consequence, the increased calcium store in the ER triggers mitochondrial changes because of calcium uptake via MCUC (b).
