Figure 4 | Scientific Reports

Figure 4

From: Topical cell-free conditioned media harvested from adipose tissue-derived stem cells promote recovery from corneal epithelial defects caused by chemical burns

Figure 4

Corneal epithelial recovery after topical administration of conditioned media (CM) harvested from rat ADSCs. Fluorescein-stained corneal pictures were taken at 0 h, 12 h, 1 day, 2 days, and 3 days after induction of chemical burn. The epithelial defect was traced and the area was measured with Image J. Significantly faster recovery from epithelial defect was observed in the CM group from the second day of injury onwards compared with the corneal burn (CB), normal control (NC) and media control (MC) groups (A,B). The epithelial differentiation in the CM group was better than that in the CB group in terms of HE staining of the cornea at 3 days (C). The epithelium layer is marked by a black arrowhead. ADSC, adipose tissue-derived stem cells; CM, conditioned media; scale bar, 1 mm and 50 μm, (A) and (B), respectively.

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