Table 2 Risk ratios for mortality and CVD event according to categories of ANGPTL8.

From: The circulating ANGPTL8 levels show differences among novel subgroups of adult patients with diabetes and are associated with mortality in the subsequent 5 years

Outcome

Model 1

Model 2

Model 3

Model 4

Mortality

All-cause mortality

 Q1 (reference)

1

1

1

1

 Q2 (RR, 95% CI)

1.63 (0.52–5.07)

1.79 (0.55–5.82)

1.53 (0.45–5.15)

1.44 (0.42–4.89)

 Q3 (RR, 95% CI)

2.27 (0.78–6.69)

1.90 (0.63–5.78)

1.82 (0.59–5.60)

1.74 (0.56–5.40)

 Q4 (RR, 95% CI)

4.86 (1.78–13.13)

3.23 (1.15–9.10)

3.28 (1.15–9.34)

3.23 (1.13–9.22)

 Per unit increase in Z score

1.66 (1.31–2.11)

1.45 (1.12–1.87)

1.51 (1.16–1.98)

1.53 (1.17–2.01)

CVD mortality

 Q1 (reference)

1

1

1

1

 Q2 (RR, 95% CI)

1.78 (0.51–6.19)

1.99 (0.55–7.26)

1.64 (0.43–6.37)

1.50 (0.38–5.83)

 Q3 (RR, 95% CI)

1.78 (0.51–6.19)

1.48 (0.41–5.33)

1.47 (0.40–5.43)

1.38 (0.37–5.15)

 Q4 (RR, 95% CI)

3.14 (0.99–9.92)

2.03 (0.61–6.72)

2.14 (0.63–7.19)

2.08 (0.62–7.05)

 Per unit increase in Z score

1.49 (1.11–1.99)

1.28 (0.93–1.76)

1.36 (0.98–1.90)

1.38 (0.99–1.93)

CVD event

 Q1 (reference)

1

1

1

1

 Q2 (RR, 95% CI)

0.85 (0.38–1.89)

0.85 (0.37–1.94)

0.79 (0.34–1.85)

0.77 (033–1.80)

 Q3 (RR, 95% CI)

0.77 (0.34–1.75)

0.64 (0.28–1.49)

0.68 (0.29–1.58)

0.64 (0.27–1.51)

 Q4 (RR, 95% CI)

1.56 (0.77–3.18)

1.07 (0.50–2.26)

1.14 (0.53–2.44)

1.11 (0.52–2.39)

 Per unit increase in Z score

1.31 (1.04–1.66)

1.16 (0.90–1.49)

1.22 (0.94–1.58)

1.22 (0.94–1.58)

  1. Model 1 was unadjusted.
  2. Model 2 was adjusted for age, sex and BMI.
  3. Model 3 was adjusted for all variables in model 2 plus HDL, LDL, TG and total cholesterol.
  4. Model 4 was adjusted for all variables in model 2 plus HDL, LDL, TG and total cholesterol, HbA1c, HOMA-IR.
  5. CVD cardiovascular disease, BMI body-mass index, HOMA-IR homeostasis model assessment of insulin resistance, HOMA-β homeostasis model assessment of β cell function, HDL high density lipoprotein, LDL low density lipoprotein, TG triglycerides.