Table 1 Summary of the comparison of MPM with histopathological stainings regarding pathological vessel wall alterations during the process of aneurysm formation.
From: Label-free multiphoton microscopy as a tool to investigate alterations of cerebral aneurysms
Unruptured | Ruptured | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Patient | 1 | 2 | 3 | 4 | 5 | 1 | 2 | 3 | 4 | 5 | |
Size (mm) | 9 × 11 × 10 | 9 | 14 × 11 × 11 | 9 | 15 × 16 × 16 | 5 | 6 | 10 × 6 | 20 | > 10 | |
OP-Age (years) | 66 | 38 | 36 | 54 | 57 | 64 | 74 | 65 | 63 | 69 | |
Location | MCA R-Bi | MCA R-Bi | MCA L-Bi | MCA R-Tri | PCoA R | ICA L-Bi | PCoA R | PCoA L | MCA L | PCoA L | |
Multiple Aneurysms | No | No | Yes | Yes | Yes | Yes | Yes | No | No | No | |
IEL Fragmented | MPM | – | – | √ | – | (√) | – | – | – | – | – |
HE | – | – | – | – | – | – | – | – | – | – | |
EvG | – | – | – | – | – | – | – | – | – | – | |
EEL Fragmented | MPM | (√) | (√) | √ | (√) | (√) | – | – | – | (√) | (√) |
HE | – | – | – | – | – | – | – | – | – | – | |
EvG | – | – | – | – | – | – | – | – | – | – | |
Elastin | MPM | √ | √ | √ | √ | √ | – | √ | – | √ | √ |
HE | – | – | – | – | – | – | – | – | – | – | |
EvG | √ | √ | (√) | √ | (√) | (√) | (√) | –– | (√) | (√) | |
Lipid | MPM | – | – | – | √ | √ | – | – | √ | √ | √ |
HE | – | – | – | – | – | – | – | – | – | – | |
Cholesterol | MPM | √ | – | – | √ | √ | – | √ | – | √ | √ |
HE | – | – | – | – | – | – | – | – | – | – | |
Calcification | MPM | – | – | – | √ | – | – | – | – | – | – |
HE | – | – | – | √ | – | – | – | – | – | – | |
Fibrotic Alterations | MPM | √ | √ | √ | (√) | √ | – | – | – | √ | √ |
HE | – | – | – | – | – | – | – | – | – | – | |
Intra-wall Heamorrhage | MPM | (√) | √ | – | (√) | – | √ | √ | √ | √ | √ |
HE | (√) | √ | – | – | – | √ | √ | √ | √ | √ | |
Disorganised SMC | MPM | √ | √ | √ | √ | √ | √ | √ | √ | (√) | √ |
HE | √ | √ | √ | √ | √ | √ | √ | √ | (√) | √ | |
Hypocellular Areas | MPM | – | – | – | – | – | – | – | – | – | – |
HE | – | – | – | √ | √ | – | – | √ | – | √ | |
Thinned Areas | MPM | – | – | – | – | – | – | – | – | – | √ |
HE | – | – | – | – | – | – | – | – | – | √ | |
Intimal Hyperplasia | MPM | √ | √ | √ | (√) | √ | √ | – | – | √ | √ |
HE | √ | √ | √ | (√) | √ | √ | – | – | √ | √ | |
Foam Cells | MPM | – | – | – | – | √ | – | – | – | – | √ |
HE | – | – | – | – | √ | – | – | – | (√) | √ | |
