Figure 3 | Scientific Reports

Figure 3

From: IL-21 Stimulates the expression and activation of cell cycle regulators and promotes cell proliferation in EBV-positive diffuse large B cell lymphoma

Figure 3

IL-21 treatment promotes angiogenesis in the NOD/SCID mouse xenograft model. (a) Epidermal blood vessels observed in the NOD/SCID mouse model. Mice treated with PBS are shown as the control group. Three representative images from different mice are shown for each group. (b) Differential expression analysis of the angiogenic genes VEGFA and VEGFB in Farage 2 days after IL-21/PBS treatment. Data are shown as the means ± SEMs (n = 3). (c) Expression of CD31 in tumour tissues from three representative NOD/SCID mice in each group was quantified by ImageJ after staining with anti-CD31 (endothelial marker) antibody. The data represent average protein levels and standard deviations in representative sections. Two-tailed t test, *P < 0.05. (d) Immunohistochemical sections of paraffin-embedded tumours from NOD/SCID mice stained with H&E and CD31-specific antibody. Three representative sections for different mice in each group are shown. The scale bar represents 100 μm.

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