Figure 6 | Scientific Reports

Figure 6

From: IL-21 Stimulates the expression and activation of cell cycle regulators and promotes cell proliferation in EBV-positive diffuse large B cell lymphoma

Figure 6The alternative text for this image may have been generated using AI.

IL-21 promotes the expression of markers of the G1/S phase transition in EBV-positive DLBCL but not in EBV-negative DLBCL cells. (a) Differential gene expression analysis of the RNA-seq data of key genes in the core molecular module in Farage cells and primary cells treated with IL-21 (100 ng/mL for 48 h) compared with expression in untreated cells.. The log2 fold changes in gene expression are shown as the means ± SEMs (n = 3). Statistical analysis was performed using FDR-based q values, and all data shown were significant with a q value of < 0.01. (b) The indicated DLBCL cell lysates were probed with the indicated antibodies. GAPDH was used as the loading control. MC116 cell line was used as an EBV-negative DLBCL comparison group. The exposure time for each protein has been indicated accordingly.

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