Figure 7 | Scientific Reports

Figure 7

From: IL-21 Stimulates the expression and activation of cell cycle regulators and promotes cell proliferation in EBV-positive diffuse large B cell lymphoma

Figure 7

Hypothetical working model of the promoted G1/S phase transition by IL-21 in EBV-positive DLBCL cells. A working model is proposed where IL-21 stimulation enhances STAT3 phosphorylation, subsequently stimulating LMP-1 expression, and establishing a positive feedback loop, resulting in upregulation of c-Myc and AP-1 expression. c-Myc and AP-1 promote restriction point transition via upregulation of cyclin D2 and cyclin E1, which promotes hyperphosphorylation of Rb, thereby promoting cell cycle progression.

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