Figure 5 | Scientific Reports

Figure 5

From: SIRT7 deficiency suppresses inflammation, induces EndoMT, and increases vascular permeability in primary pulmonary endothelial cells

Figure 5

Effects of SIRT7 silencing on pro-fibrotic gene expression in primary pulmonary endothelial cells. mRNA levels of each indicated RT-qPCR target in CTRL-silenced (□) or SIRT7-silenced (■) HPAEC cultures were normalized to GAPDH and expressed as fold changes relative to average mRNA levels in unstimulated (LPS 0), CTRL-silenced cell cultures. Bars represent averages and brackets standard deviations of measurements for two samples per condition. P values were calculated using the Student’s t test. Significant differences (P < 0.05) between and CTRL- and SIRT7-silenced cultures for each LPS concentration are denoted by stars.

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