Table 1 Risk markers of cardiovascular dysfunction in db/db mice compared to their wild type control (db/ +).

From: Identification of potential biomarkers for predicting the early onset of diabetic cardiomyopathy in a mouse model

 

Wild type (db/ +)

Obese (db/db)

6 weeks

9 weeks

11 weeks

14 weeks

16 weeks

6 weeks

9 weeks

11 weeks

14 weeks

16 weeks

BW (g)/tibia length (mm)

1.21 ± 0.03

1.28 ± 0.06

1.34 ± 0.03

1.38 ± 0.02

1.33 ± 0.03

1.68 ± 0.06***

1.96 ± 0.03***

2.11 ± 0.07***

1.80 ± 0.14***

1.69 ± 0.11**

FBG (mmol/L)

8.33 ± 0.58

7.09 ± 0.29

8.91 ± 5.15

6.94 ± 0.71

10.46 ± 8.07

12.50 ± 0.52

22.74 ± 2.76***

28.30 ± 1.88***

29.50 ± 1.44***

27.33 ± 9.20***

Cholesterol (mol/L)

1.90 ± 0.07

2.37 ± 0.41

1.75 ± 0.03

1.85 ± 0.05

2.12 ± 0.17

3.90 ± 0.21***

3.45 ± 0.59*

3.79 ± 0.24**

3.90 ± 0.34**

3.77 ± 0.20***

LDL (mmol/L)

0.30 ± 0.00

0.30 ± 0.00

n/a

0.30 ± 0.00

0.30 ± 0.00

0.55 ± 0.05**

0.37 ± 0.08

n/a

0.50 ± 0.15

0.53 ± 0.10**

Triglycerides (mmol/L)

0.84 ± 0.14

0.77 ± 0.08

n/a

1.10 ± 0.13

0.78 ± 0.17

2.43 ± 0.22**

2.10 ± 0.56

n/a

3.11 ± 0.36

1.86 ± 0.65**

  1. BW body weight, LDL low-density lipoprotein, FBG fasting blood glucose levels.
  2. *p ≤ 0.015, **p < 0.01 ***p ≤ 0.001 versus wild type control (db/ +) at the same time point.
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