Figure 6
From: β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells
Schematic illustrating of regulation of mechanical stimulation-induced collagen expression through integrins. Integrins including integrin β1 bind to the ECM, transmit mechanical stimulation intracellularly, and activate ILK to phosphorylate AKT. AKT induces the mTOR pathway which leads to phosphorylation of S6 and 4E-BP. These events result in stimulation of collagen synthesis.
