Figure 2 | Scientific Reports

Figure 2

From: Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infants

Figure 2

Neonatal hyperoxia exposure reduces lung and circulating Klotho levels. Decreased (a) lung Klotho mRNA and (b) protein expression in rats exposed to 14 and 21 days hyperoxia. Klotho gene and protein expression were normalized to GAPDH and β-Actin respectively. A representative Western blot is shown in the lower panel. (c) Reduced circulating Klotho levels in rodents exposed to 14 and 21 days hyperoxia. White bars indicate normoxia, and black bars indicate hyperoxia (data are mean ± SEM; **P < 0.001, *P < 0.05; normoxia vs hyperoxia; N = 4–5/group).

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