Table 2 Logistic regression analysis for stress-induced myocardial ischemia.

From: Plasma extracellular vesicle proteins are associated with stress-induced myocardial ischemia in women presenting with chest pain

Biomarker

Unadjusted

RF adjusteda

RF + Med Adjustedb

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

Serpin C1 HDL

1.31 (1.04–1.66)

0.024

1.38 (1.05–1.80)

0.017

1.39 (1.06–1.82)

0.017

Serpin C1 LDL

1.35 (0.91–2.01)

0.135

1.33 (0.86–2.05)

0.204

1.29 (0.83–2.01)

0.252

Serpin C1 TEX

0.87 (0.52–1.44)

0.581

0.79 (0.46–1.37)

0.400

0.80 (0.46–1.39)

0.428

CD14 HDL

1.46 (1.01–2.11)

0.042

1.56 (1.04–2.35)

0.032

1.62 (1.07–2.45)

0.023

CD14 LDL

1.54 (1.09–2.16)

0.014

1.62 (1.11–2.35)

0.013

1.64 (1.12–2.41)

0.011

CD14 TEX

1.52 (0.83–2.78)

0.172

1.43 (0.74–2.75)

0.288

1.50 (0.77–2.92)

0.230

Serpin G1 HDL

1.37 (1.04–1.80)

0.027

1.42 (1.05–1.92)

0.024

1.41 (1.04–1.92)

0.028

Serpin G1 LDL

1.04 (0.76–1.43)

0.810

1.24 (0.87–1.75)

0.230

1.27 (0.90–1.81)

0.179

Serpin G1 TEX

1.08 (0.68–1.73)

0.737

1.27 (0.74–2.17)

0.393

1.25 (0.72–2.19)

0.432

Cystatin C HDL

1.35 (1.04–1.76)

0.026

1.38 (1.03–1.85)

0.034

1.41 (1.04–1.91)

0.025

Cystatin C LDL

1.70 (1.17–2.46)

0.006

1.69 (1.11–2.55)

0.014

1.70 (1.12–2.60)

0.014

Cystatin C TEX

1.45 (0.81–2.58)

0.210

1.14 (0.59–2.21)

0.694

1.13 (0.58–2.20)

0.726

Serpin F2 HDL

1.00 (0.82–1.22)

0.967

1.07 (0.87–1.32)

0.519

1.07 (0.87–1.32)

0.521

Serpin F2 LDL

0.99 (0.82–1.21)

0.945

1.03 (0.84–1.27)

0.772

1.02 (0.83–1.26)

0.825

Serpin F2 TEX

0.89 (0.63–1.24)

0.480

0.92 (0.63–1.30)

0.582

0.94 (0.65–1.36)

0.738

Plasminogen LDL

1.16 (0.78–1.71)

0.468

1.28 (0.83–1.96)

0.262

1.32 (0.85–2.04)

0.212

Plasminogen TEX

1.02 (0.63–1.64)

0.950

0.92 (0.55–1.54)

0.755

0.94 (0.56–1.57)

0.804

  1. Biomarker levels are log-transformed and standardized per synthetic vesicle and shown as mean ± SD. Original assay units are pg/ml.
  2. RF Risk factor, Med medication.
  3. aRF adjusted; age, sex, hypertension, hypercholesterolemia, smoking, diabetes mellitus and coronary artery disease.
  4. bRF + Med adjusted: platelet inhibitors and blood pressure lowering agents.
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