Table 3 Changes of hematological examination before and after medication.

From: Leflunomide monotherapy versus combination therapy with conventional synthetic disease-modifying antirheumatic drugs for rheumatoid arthritis: a retrospective study

Characteristic

Monotherapy group

Combination group

Premedication (n = 43)

Post-medication (n = 18)

Δ

Premedication (n = 151)

Post-medication (n = 106)

Δ

Blood routine

HGB, g/L

128.83 (15.58)

131.92 (13.07)

3.09

123.91 (15.96)

123.83 (19.70)

− 0.08

RBC, 1012/L

4.24 (0.39)

4.33 (0.38)

0.09

4.22 (0.61)

4.26 (0.58)

0.04

MCV, fL

92.71 (4.68)

94.26 (6.83)

1.55

91.45 (7.25)

91.66 (8.21)

0.21

WBC, 109/L

6.07 (1.72)

5.63 (1.32)

− 0.44

6.21 (2.06)

5.46 (1.85)

− 0.75

Liver results

ALB, g/L

43.92 (5.10)

45.04 (3.86)

1.12

43.15 (4.07)

43.72 (4.23)

0.57

AST, U/L

23.10 (9.87)

23.47 (7.73)

0.37

24.17 (10.80)

27.31 (13.64)

3.14

ALT, U/L

19.97 (7.34)

27.89 (17.95)

7.92

22.83 (12.21)

26.85 (14.99)

4.02

Kidney results

GFR, mL/min

84.70 (23.77)

94.83 (13.53)

10.13

89.60 (28.84)

86.85 (24.14)

− 2.75

Scr, μmol/L

61.98 (11.86)

52.09 (10.87)

− 9.89

53.11 (10.89)

58.21 (19.39)

5.10

  1. Values are means (SD).
  2. HGB hemoglobin, RBC red blood cell, MCV mean corpuscular volume, WBC white blood cell, ALB albumin, AST aspartate transaminase, ALT alanine transaminase, GFR glomerular filtration rate, Scr serum creatinine, Δ the change before and after medication.
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