Figure 7
The combination of BI2536 and nocodazole efficiently diminishes the clonogenicity of advanced PCa cells. (a) Colony formation assays for the DU145 cell line treated with BI2536 or NoC alone or in combination (combo), or with DMSO (vehicle) for 10–14 days. (b) Quantified results were expressed as a percentage of the Control (DMSO) group, setting at 100%. Data are expressed as mean ± SD of three independent experiments (*p < 0.05; **p < 0.01, ***p < 0.001). (c) The combination index (CI) for BI2536 and NoC treatment of DU145 cells were calculated using the Calcusyn program.
