Table 2 Urinary excretion of glycation, oxidation and nitration free adducts (nmol/mg creatinine).

From: High fractional excretion of glycation adducts is associated with subsequent early decline in renal function in type 1 diabetes

Urinary free adduct

Normoalbuminuria (n = 30)

Microalbuminuria (n = 55)

P value NA vs. MA*

P value NA and stable GFR vs. early GFR decline*

Stable GFR (n = 33)

Early GFR decline (n = 22)

FL

32.0 [22.3–42.3]

37.5 [13.5–71.7]

60.6 [30.9–99.4]

  

CML

3.30 [2.33–4.70]

2.63 [1.11–5.94]

4.04 [2.87–8.45]

  

CEL

1.22 [0.90–1.61]

1.06 [0.42–2.53]

1.80 [1.18–3.29]

  

G-H1

1.92 [1.29–2.39]

1.42 [0.42–2.99]

1.78 [1.33–2.64]

  

MG-H1

61.9 [30.4–92.3]

42.7 [13.0–93.1]

51.9 [29.2–155.3]

  

3DG-H

1.34 [1.04–1.94]

0.80 [0.39–1.65]

1.42 [0.74–1.95]

  

CMA

1.61 [1.25–2.24]

1.70 [0.66–3.66]

2.04 [1.36–4.03]

  

GOLD

0.0126 [0.0092–0.0207]

0.0189 [0.0057–0.0243]

0.0204 [0.0101–0.0249]

  

MOLD

0.069 [0.050–0.107]

0.097 [0.065–0.139]

0.109 [0.076–0.158]

  

Pentosidine

0.0102 [0.0064–0.0170]

0.0313 [0.0144–0.0905]

0.0561 [0.0273–0.1027]

 < 0.0001

 < 0.01

MetSO

1.12 [0.56–1.93]

0.83 [0.44–1.64]

0.60 [0.30–1.20]

  

DT

0.0529 [0.0404–0.0639]

0.0325 [0.0175–0.1036]

0.0547 [0.0392–0.0950]

  

NFK

0.285 [0.205–0.352]

0.138 [0.042–0.320]

0.189 [0.077–0.282]

  

3-NT

0.0094 [0.0041–0.0169]

0.0136 [0.0045–0.0301]

0.0117 [0.0050–0.0369]

  
  1. Data are median [interquartile range]. *A Bonferroni correction of 14 was applied. Data from 3 patients are missing (2 from MA with stable renal function and one from MA with early decline in renal function).
Back to article page