Table 3 Fractional Excretion of Protein Glycation, Oxidation and Nitration Free Adducts (%).

From: High fractional excretion of glycation adducts is associated with subsequent early decline in renal function in type 1 diabetes

Free adduct

Normoalbuminuria (n = 30)

Microalbuminuria (n = 55)

P value (NA vs MA)

NA and stable GFR (n = 63)

Early GFR decline (n = 22)

P value stable vs early GFR decline

FL

100 [54–160]

153 [79–247]

 

100 [58–204]

204 [114–257]

 < 0.05

CML

30.4 [25.0–39.4]

43.6 [22.1–71.9]

 

30.6 [21.7–43.5]

52.3 [44.8–81.9]

 < 0.01*

CEL

26.4 [16.0–33.7]

28.3 [18.1–52.9]

 

25.1 [12.6–34.4]

42.4 [26.0–52.0]

 < 0.05

G-H1

30.7 [15.0–60.0]

14.5 [5.3–30.0]

 < 0.01*

19.6 [6.9–39.6]

17.9 [13.4–44.1]

 

MG-H1

113 [91 -146]

123 [73–263]

 

111 [71–156]

182 [115–290]

 < 0.05

3DG-H

15.0 [11.6–23.5]

15.8 [8.4–27.9]

 

14.0 [8.9–22.7]

19.8 [14.1–39.9]

 

CMA

4.3 [2.9–5.6]

22.4 [7.2–57.5]

 < 0.001*

6.0 [3.9–23.6]

32.2 [7.6–89.6]

 < 0.001*

Pentosidine

8.8 [5.0–20.3]

97.1 [38.2–141.1]

 < 0.001*

20.9 [7.3–94.9]

109.1 [74.6–143.8]

 < 0.001*

ΣERFD predictors

285 [223–387]

537 [293–867]

 < 0.05*

337 [217–526]

785 [499–991]

 < 0.001*

MetSO

0.8 [0.3–1.6]

0.6 [0.4–1.3]

 

0.7 [0.3–1.5]

0.6 [0.4–1.4]

 

DT

26.7 [20.9–43.8]

27.8 [12.5–56.8]

 

26.6 [15.6–50.6]

29.4 [19.0–49.7]

 

NFK

8.8 [5.7–14.3]

6.6 [2.6–10.7]

 

7.7 [3.5–11.0]

9.2 [3.7–12.1]

 

3-NT

10.5 [4.2–29.4]

13.4 [5.7–26.6]

 

13.3 [4.6–26.5]

11.8 [7.7–30.5]

 
  1. Data are median [interquartile range]. Statistical analysis was performed using the Student’s t-test of log-transformed values. *Significance of difference remained significant after a Bonferroni correction of 12 was applied. Data from 3 patients are missing (2 from MA with stable renal function and one from MA with early decline in renal function). ΣERFD predictors is the sum of FE values for FL, CML, CEL, MG-G1, CMA and pentosidine.
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