Figure 2 | Scientific Reports

Figure 2

From: A non-pharmacological therapeutic approach in the gut triggers distal metabolic rewiring capable of ameliorating diet-induced dysfunctions encompassed by metabolic syndrome

Figure 2

Hepatic transcriptional reprogramming induced by Policaptil Gel Retard. (a) left Venn diagram of genes whose expression is significantly increased at ZT12 compared to ZT0 in both groups (507), controls only (420) and Policaptil Gel Retard only (412) (n = 3, Cyber t-test p < 0.05; ZT Zeitgeber time). (a) right Heat map of genes significantly up-regulated between ZT0 and ZT12 in vehicle (Cntrl) or Policaptil Gel Retard (Policaptil Gel Retard) treated mice (n = 3, Cyber t-test p < 0.05). (b) Gene ontology analysis of genes induced at ZT12 in control mice. (c) Top 10 results for TF binding sites from ENCODE and ChEA in control mice. (d) Gene ontology analysis of genes induced at ZT12 in Policaptil Gel Retard treated mice. (e) Top 10 results for TF binding sites from ENCODE and ChEA in Policaptil Gel Retard treated mice.

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