Figure 2
From: In vivo effect of magnetic microspheres loaded with E2-a in the treatment of alveolar echinococcosis
In vivo treatment of E. multilocularis infected mice with PLGA-Fe-E2-a. BALB/c mice were intraperitoneally infected with E. multilocularis metacestodes. At the 14th week after infection, mice with secondary alveolar echinococcosis were treated with PBS, albendazole (100 mg/kg/day), E2-a (50 mg/kg/day) or PLGA-Fe-E2-a (50 mg/kg/3 day). After six weeks of treatment, mice were sacrificed. The parasite cysts were resected and weighted. Macroscopic (A), the representative pathological characteristics (H&E stain, magnification 100 ×). Samples of parasite vesicles were processed for haematoxylin and eosin (H&E) staining (B). Samples of cysts were used to scanning electron microscopy (SEM) examination (C,D). Note the distorted morphology of the germinal layer (GL) in those specimens treated with PLGA-Fe-E2-a. GC germinal layer, LL laminated layer. Bar = 10 μm (C) or 50 μm (D).
