Table 2 Between-group comparison of activated and deactivated brain regions during task 1 in patients with essential tremor (ET) and healthy controls (HC).

ROI	Voxels	MAX Z-statistic	MAX X (mm)	MAX Y (mm)	MAX Z (mm)
ACTIVATIONS
*TASK 1—ET > HC*
FP.l	717	8.26	66	84	39
PRG.r/MFG.r	326	7.75	19	66	48
FP.r	261	9	32	88	31
Caud.r	111	6.19	36	75	34
PRG.l	101	8.47	61	58	60
*TASK 1—ET < HC*
CER.r	484	7.52	42	40	32
HIPP.r	201	7.17	31	59	26
POG.l	105	7.4	61	45	64
THL.l/Caud.l	104	5.45	51	56	45
SMA	101	6.16	48	51	61
DEACTIVATIONS
*TASK 1—ET > HC*
CER.l	8593	− 15.4	48	19	18
PRG.r/POG.r/LOC.r	3776	− 9.73	28	39	55
PRG.l/POG.l/LOC.l/SMA	3279	− 10.3	67	32	51
CER.r	1588	− 11.4	35	18	17
PAC	342	− 6.84	48	75	59
CGp.l	281	− 8.66	47	41	45
FP.r	252	− 6.73	25	88	49
AMY.r	178	− 7.36	32	60	28
THL.r/Caud.r/THL.l/Caud.l	122	− 6.4	36	53	42
*TASK 1—ET < HC*
FP.l	100	− 7.9	61	83	52

Voxels, number of voxels in each significant cluster; MAX Z-statistic, value of the maximum z-statistic within the cluster; MAX X/Y/Z (mm), location of the maximum intensity voxel, given as spatial coordinate values in standard space (mm). For all clusters, the corresponding p values are FWE-corrected and < 0.05. For ease of reading, a cluster size of at least 100 voxels has been chosen for reporting the significant clusters resulting from the statistical comparisons.
AMY, amygdala; Caud, caudate; CER, cerebellum; CGp, posterior cingulate gyrus; ET, patients with essential tremor; FP, frontal pole; FWE, family-wise error; HC, healthy controls; HIPP, hippocampus; l, left; LOC, lateral occipital cortex; MFG, middle frontal gyrus; PAC, paracingulate gyrus; POG, postcentral gyrus; PRG, precentral gyrus; r, right; ROI, region of interest; SMA, supplementary motor areas; THL, thalamus.

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